In which situation is a handshake considered inappropriate?

A handshake is considered a common gesture of greeting, respect, and professionalism in many contexts. However, when one person is ill, a handshake can be inappropriate due to health concerns. If one party is sick, especially with a contagious illness, initiating a handshake can put the other person at risk of catching the illness.

In contrast, during a job interview, at a networking event, and when meeting someone new, a handshake is generally regarded as a positive and professional way to establish rapport and convey confidence. In those situations, the act of shaking hands helps to create a welcoming environment and fosters a sense of connection, making the handshake an appropriate gesture.